Cotinine tests measure the presence of nicotine in urine. Cotinine is produced after exposure to nicotine. Measuring cotinine is more effective because nicotine disappears after a few hours although cotinine remains longer. Cotinine tests uses a urine specimen.
Cotinine is usually the ideal choice to evaluate tobacco use or exposure to nicotine found in tobacco products and because it is stable and is only produced when nicotine is metabolized. Cotinine has a half-life in the body of between 7 and 41 hours, while nicotine has a half-life of 1 to 4.5 hours.
Nicotine is an addictive chemical found naturally in the tobacco plant and in some manufactured products, such as some e-cigarettes and nicotine-replacement products (e.g., gum, patch). It is inhaled or ingested and subsequently absorbed into the blood.
This testing detects and/or measures nicotine and its primary breakdown product (metabolite) cotinine in the blood, urine, saliva, or hair. Nicotine is metabolized by the liver...